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Statement [Line Items] Statement [Line Items] Business Combination [Domain] Business Acquisition, Acquiree Entity Filer Category Entity Filer Category Reclassification, Comparability Adjustment [Policy Text Block] Reclassifications Variable consideration Variable Consideration Variable consideration. Liabilities and Equity Total liabilities and stockholders’ equity Payables and Accruals [Abstract] Milestone payment upon commencement of clinical trials in humans Milestone Fee Payments Upon Commencement Of Clinical Trials Milestone fee payments upon commencement of clinical trials. Payments to Acquire Marketable Securities Purchases of marketable debt securities Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price Weighted-average Exercise Price, Exercisable Restructuring Type [Axis] Long-Lived Tangible Asset [Axis] Long-Lived Tangible Asset Cash equivalents and marketable securities. 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Nontaxable or nondeductible items: Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount [Abstract] Investment, Name [Axis] Earnings Per Share, Basic Basic net income (loss) per share Earnings Per Share, Basic, Total Net loss per share, basic Vesting of restricted stock units Vesting Of Restricted Stock Units Vesting of restricted stock units, net of tax Stock Issued During Period Value Pre Funded Warrants Exercised Stock Issued During Period Value Pre Funded Warrants Exercised Exercise of pre-funded warrants OCI, Debt Securities, Available-for-Sale, Gain (Loss), before Adjustment and Tax Unrealized gain (loss) on available-for-sale securities, net Service Agreements [Member] Service Agreements [Member] Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number Shares Outstanding, Ending Balance Shares Outstanding, Beginning Balance Accrued expenses and other current liabilities. Accrued Expenses And Other Current Liabilities Accrued expenses and other current liabilities Accrued expenses and other current liabilities Liabilities, Current Total current liabilities Non-marketable equity securities. Non Marketable Equity Securities Policy [Text Block] Non-marketable Equity Securities Other Past or Future Obligations to Pay Sublicense Fees [Member] Other Past Or Future Obligations To Pay Sublicense Fees [Member] Other Past or Future Obligations to Pay Sublicense Fees. Increase (Decrease) in Accounts Receivable Accounts receivable Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract] Adjustments to reconcile net loss to net cash used in operating activities Lessee, Operating Lease, Liability, to be Paid, Year Five 2030 Revenue, Major Customer [Line Items] Entity Wide Revenue Major Customer [Line Items] Income Tax Paid, Federal, after Refund Received Income Tax Paid, Federal, after Refund Received, Total Federal Domestic Tax Jurisdiction [Member] Domestic Country [Member] Royalty Agreements [Member] Royalty Agreements Share Repurchase Program [Domain] Tax credits: Effective Income Tax Rate Reconciliation, Tax Credit, Percent [Abstract] Financing Receivable, Allowance for Credit Loss [Line Items] Financing Receivable Allowance For Credit Losses [Line Items] Effective Income Tax Rate Reconciliation, Tax Credit, Other, Amount Other tax credits Other tax credits Proceeds from Sale and Maturity of Debt Securities, Available-for-Sale Sales of equity securities Proceeds from Sale and Maturity of Debt Securities, Available-for-Sale, Total Effective Income Tax Rate Reconciliation [Table] Accounts receivable (net of allowance of $4,152 as of December 31, 2022) Accounts receivable Non-current accounts receivable Accounts receivable, Non current Accounting Standards Update [Axis] Accounting Standards Update Other current assets. Other Current Assets [Line Items] Consolidation Items [Domain] Equity, Attributable to Parent [Abstract] Stockholders’ equity Entity Small Business Entity Small Business Retained Earnings (Accumulated Deficit) Accumulated deficit Retained Earnings (Accumulated Deficit), Total Other license and royalty revenue. Other License And Royalty Revenue Other Accounting Standards Update 2016-02 [Member] ASU 2016-02 [Member] Net proceeds allocated to Royalty Bond Net proceeds allocated to royalty bond. Proceeds from royalty bond, net of discount and issuance costs Other Commitments [Line Items] Other Commitments [Line Items] Nature of Operations [Text Block] Nature of Business Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Amount Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Amount, Total Effects of cross-border tax laws Entity Well-known Seasoned Issuer Entity Well-known Seasoned Issuer Change in transaction price Change In Transaction Price Of License Change in transaction price of license. 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Contract with Customer, Liability Deferred revenue, current and non-current Contract with Customer, Liability, Total Balance, end of period Balance, beginning of period Amendment Flag Amendment Flag Debt and Equity Securities, Realized Gain (Loss) Realized Gain Debt and Equity Securities, Realized Gain (Loss), Total Unrealized gain (loss) before reclassifications OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment and Tax Unrealized loss before reclassifications Product and Service [Domain] Product and Service Lessee, Operating Lease, Lease Not yet Commenced, Option to Terminate Lease not yet commenced, option to terminate the lease, description Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount U.S. federal statutory tax rate Direct Development And Support [Member] Direct development and support. Direct development and support Number of warrants issued Class of Warrant or Right, Number of Securities Called by Warrants or Rights Earnings Per Share, Policy [Policy Text Block] Net Loss Per Share Liabilities and Equity [Abstract] Liabilities and Stockholders’ Equity Income tax disclosure. Income Tax Disclosure [Table] Income Tax Disclosure [Table] Entity Address, Postal Zip Code Entity Address, Postal Zip Code Royalty payment cap amount Royalty Payment Cap Amount Royalty Payment Cap Amount Cash Provided by (Used in) Operating Activity, Including Discontinued Operation Net cash used in operating activities Contract assets. Contract Assets [Member] Contract Assets [Member] Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description Common Stock [Member] Common Stock [Member] Rule 10b51 Trading Plan Three [Member] Rule 10b51 trading plan three. Proceeds from issuance of royalty bond and warrants, net of transaction costs Proceeds From Issuance Of Royalty Bond And Warrants Net Of Transaction Costs Proceeds from issuance of royalty bond and warrants net of transaction costs. Cybersecurity Risk Role of Management [Text Block] Tax Credit Carryforward, Amount Tax credit carryforwards Non-marketable equity securities had carrying value. 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Customer D [Member] Customer D [Member] May two thousand twenty five warrants [Member] May two thousand twenty five warrants. May 2025 Warrants [Member] Income Tax Paid, by Individual Jurisdiction [Line Items] Debt Instrument, Interest Rate, Effective Percentage Interest Rate, Effective Percentage Entity Address, Address Line One Entity Address, Address Line One Deferred Tax Liabilities, Gross Total deferred tax liabilities Deferred Tax Liabilities, Gross, Total Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Schedule of Fair Value of Options Granted on Weighted-Average Assumptions Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV Earnings Per Share [Abstract] Income Tax, Policy [Policy Text Block] Income Taxes Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag] Supplemental Cash Flow Information [Abstract] Supplemental cash flow information Foreign Currency Transactions and Translations Policy [Policy Text Block] Foreign Currency Transactions Litigation Settlement, Amount Awarded from Other Party Settlement amount received Name of Property [Axis] Name of Property Statement of Financial Position Location, Balance [Axis] Balance Sheet Location Investment Type [Axis] Investment Type Operating Lease, Right-of-Use Asset Operating lease right-of-use assets Debt Securities, Available-for-Sale, Unrealized Loss Position Total, Fair Value Total deferred tax assets before valuation allowance Deferred Tax Assets, Gross Aggregate transaction price of license agreements Aggregate Transaction Price Of License Agreements Aggregate transaction price of license agreements. 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Auditor Firm ID Auditor Firm ID Accounts Receivable, before Allowance for Credit Loss, Current Accounts receivable, current Accounts receivable, Current Capitalized Computer Software, Net, Total Capitalized Computer Software, Net, Beginning Balance Capitalized Computer Software, Net, Ending Balance Capitalized Computer Software, Net Capitalized costs net Schedule of cash and cash equivalents and restricted cash. Schedule Of Cash And Cash Equivalents And Restricted Cash Table [Text Block] Summary of Reconciliation of Cash and Cash Equivalents and Restricted Cash Provision for Other Credit Losses Provision for credit losses (recoveries) Credit losses (recoveries) Concentration Risk Benchmark [Axis] Concentration Risk Benchmark Milestone Fee Received Upon Achievement Of Specified Development And Sales Based Milestones Milestone fee received upon achievement of specified development and sales based milestones. 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